Papel de la microbiota intestinal en el desarrollo de la enfermedad de Alzheimer

Irene Fernández Martín

doi:10.18002/ambioc.v0i18.6565

Autores/as

Irene Fernández Martín

DOI:

https://doi.org/10.18002/ambioc.v0i18.6565

Palabras clave:

Disbiosis, eje microbiota-intestino-cerebro, enfermedad de Alzheimer, microbiota, neuroinflamación

Resumen

La enfermedad de Alzheimer (EA) es una enfermedad de carácter neurodegenerativo y la principal causa de demencia en el mundo. Cada vez más hipótesis apuntan a que es una enfermedad de origen intestinal: su patogénesis se ha relacionado con el eje microbiota-intestino-cerebro, y se especula que el desequilibrio intestinal puede estar vinculado con el desarrollo de la EA. La disbiosis hace que ciertos productos microbianos (amiloides, lipopolisacáridos y neurotransmisores) puedan atravesar la barrera intestinal y la hematoencefálica (BHE) y llegar al sistema nervioso central (SNC) aumentando el riesgo de padecer EA. En definitiva, la salud del SNC depende en gran medida de la salud de la microbiota intestinal y por ello los posibles tratamientos que se investigan para la EA se centran principalmente en la modulación de la microbiota mediante el uso de probióticos, prebióticos, trasplante de microbiota fecal y ejercicio físico.

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Citas

Aguayo, S., Schuh, C. M. A. P., Vicente, B. y Aguayo, L. G. 2018. Association between Alzheimer´s disease and oral and gut microbiota: are pore forming proteins the missing link?, Journal of Alzheimer´s Disease, 65:29-46

Angelucci, F., Cechova, K., Amlerova, J. y Hort, J. 2019. Antibiotics, gut microbiota, and Alzheimer´s disease, Journal of Neuroinflammation, 16:108

Barragán, D., García, M. A., Parra, A. y Tejero, J. 2019. Enfermedad de Alzheimer, Medicine, 12:4338-4346

Bondi, M. W., Edmonds, E. C., y Salmon, D. P. 2017. Alzheimer´s disease: past,

present and future, Journal of the International Neuropsychological Society, 23:818-831

Calsolaro, V. y Edison, P. 2016. Neuroinflammation in Alzheimer´s disease: current evidence and future directions, Alzheimer´s & Dementia: the Journal of the Alzheimer´s Association, 12:719- 732

Campdelacreu, J. 2012. Enfermedad de Parkinson y enfermedad de Alzheimer:

factores de riesgo ambientales, Neurología, 29:541-549

Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y. y Wu, Q. 2017. Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer´s disease in rodent models by targeting the microbiota-gut-brain axis, Frontiers in Aging Neuroscience, 9(403)

Cummings, J. 2002. Alzheimer disease, Amerian Medical Association, 287:2335-2338

Distrutti, E., O´Reilly, J., McDonald, C., Cipriani, S., Renga, B., Lynch, M. M. y

Fiorucci, S. 2014. Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP, Plos ONE, 9:1-11

Giau, V. V., Wu, S. Y., Jamerlan, A., An, S. S. A., Kim, S. Y. y Hulme, J. 2018. Gut

microbiota and their neuroinflammatory implications in Alzheimer´s disease, Nutrients, 10:1765

Hill, J. M., Bhattacharjee, S., Pogue, A. I. y Lukiw, J. 2014. The gastrointestinal tract microbiome and potential link to Alzheimer´s disesase, Frontiers in Neurology, 5:1-4

Hu, X., Wang, T. y Jin, F. 2016. Alzheimer´s disease and gut microbiota, Science

China, 59:1006-1023

Jiang, C., Li, G., Huang, P., Liu, Z. y Zhao, B. 2017. The gut microbiota and Alzheimer´s disease, Journal of Alzheimer´s Disease, 58:1-15

Karl, J. P., Margolis, L. M., Madslien, E. H., Murphy, N. E., Castellani, J. W., Gundersen, Y., Hoke, A. V., Levangie, M. W., Kumar, R., Chakraborty, N., et al. 2017. Changes in intestinal microbiota composition and metabolism

coincide with increased intestinal permeability in young adults under prolonged physiological stress, American Journal of Physiology. Gastrointestinal and Liver Physiology, 312:559-571

Kim, S. y Jazwinski, S. M. 2019. The gut microbiota and healthy aging, Gerontology, 64:513- 520.

Kowalski, K. y Mulak, A. 2019. Brain-gut-microbiota axis in Alzheimer´s disease, Journal of Neurogastroenterology and Motility, 25:48-60

Lindsay, J., Laurin, D., Verreault, R., Hébert, R., Helliwell, B., Hill, G. B. y McDowell, I. 2002. Risk factors for Alzheimer´s disease: a prospective analysis from the canadian study of health and aging, American Journal of Epidemiology, 156:445-453

Liu, X., Cao, S. y Zhang, X. 2015 Modulation of gut microbiota-brain axis by probiotics, prebiotics, and diet, Journal of Agricultural and Food Chemistry, 63:7885-7895

Luca, M., Di Mauro, M., Di Mauro, M. y Luca, A. 2019. Gut microbiota in Alzheimer´s disease, depression, and type 2 diabetes mellitus: the role of oxidative stress, Oxidative Medicine and Cellular Longevity, 2019, 1-10

Passos, M. C. F y Morales-Filho, J. P. 2017. Intestinal microbiota in digestive diseases, Arquivos de Gastreoenterologia, 54:255-262

Reitz, C., Brayne, C. y Mayeux, R. 2011. Epidemiology of Alzheimer´s disease, Nature Reviews Neurology, 7:137-152

Reitz, C. y Mayeux, R. 2014. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers, Biochemical Pharmacology, 88:640-651

Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A. y Mele, M. C. 2019. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet and disease, Microorganisms, 7:1-22

Sánchez, B., Delgado, S., Blanco-Mínguez, A., Lourenço, A., Gueimonde, M. y Margolles, A. 2017. Probiotics, gut microbiota, and their influence on host health and disease, Molecular Nutrition & Food Research, 61(1)

Serrano-Pozo, A. y Growdon, J. H. 2019. Is Alzheimer´s disease risk modifiable?,

Journal of Alzheimer´s Disease, 67:795-819

Shen, T-C. D. 2017. Diet and gut microbiota in health and disease, Nestle Nutrition Institute Workshop Series, 88:117-126

Silva, M. V. F., Loures, C. de M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., y Carvalho, M. das G. 2019. Alzheimer´s disease: risk factors and potentially protective measures, Journal of Biomedical Science, 26:1-11

Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song,

Z., Chen, D. y Liu, J. 2019. Fecal microbiota transplantation alleviated Alzheimer´s disease-like pathogenesis in APP/PS1 transgenic mice, Translational Psychiatry, 9:1-13

Szablewski, L. 2017. Human gut microbiota in health and Alzeimer´s disease,

Journal of Alzheimer´s Disease, 62:549-560

W o r l d H e a l t h O r g a n i s a t i o n ( 2 0 1 9 ) D e m e n t i a . D i s p o n i b l e e n : https://www.who.int/news-room/fact-sheets/detail/dementia (Accedido: 26 de febrero de 2020)