Investigaciones sobre la eficacia de la Methiridina y del Thiabendazol frente a Trichinella spiralis (Owen, 1835) Railliet, 1895

Abstract

Some tests have been carried out on the therapeutic efficiciency of Methiridine and of Thiabendazol in rats and in hamsters against a Trichhinella spiralis.
Methiridine at a dosage of 800, 200 and 200 mg./kg. showed a 100 % efficiency when administered against adult intestinal worms at 3rd., 6th., and 9 th. days post infestatio. Its efficiency diminished when administered against emigrant larvas, but it has been shown that it kills said larvas or prevent their growth.
Thiabendazol was administered at a dosage between 50 and 250 mg./kg. in rats and of 500 mg./kg. in hamsters. The maximum effect obtained (99.5 % of reduction or increase) was reached with 250 mg./kg,. 3 days, against adult intestinal worms. In all the experiments or tests, except in that using 50 mg./kg., 3 days, against Trichinella in preadult worms, a secondary effect of Thiabendazol was shown ( on the second generation). The maximum efficiency was obtained by administering 250 mg./kg., 3 days, against emigrant larvas. When testing a same do­sage at different time of biological cycle it was observed that the direct effects of the product on intestinal worms diminished in a progressive way with the cycle though it maintained its secondary action upon the next generation. This was observed in the rats but not in the hamsters under test