Investigación básica sobre hepatocarcinoma en la Universidad de León

Autores

  • José L. Mauriz
  • Sara Carbajo Pescador
  • Javier Martín Renedo

DOI:

https://doi.org/10.18002/ambioc.v0i9.4934

Palavras-chave:

Medicina. Salud, Cáncer, Hepatocarcinoma, Investigación, Quimioterapia,

Resumo

Estudio de nuevas estrategias quimioterapéuticas en el tratamiento del hepatocarcinoma humano

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Referências

Bosh, F.X., Ribes, J. y Borras, J. (1999). Epidemiology of primary liver cáncer. Semin Liver Dis. 19:271-285.

Bruix, J., Calvet, X., Costa, J., Ventura, M., Bruguera, M., Castill, R., Barrera, J.M., Ercilla, G., Sánchez-Tapias, J.M., Vall, M., Bru, C. y Rodés, J. (1989). Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 3:1004-1006.

Carbajo-Pescador, S., García-Palomo, A., Martín-Renedo, J., Piva, M., González- Gallego, J. y Mauriz, J.L. (2011). Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. J Pineal Res. 51:463-467.

Carbajo-Pescador, S., Martín-Renedo, J., García-Palomo, A., Tuñón, M.J., Mauriz, J.L. y González-Gallego J. (2009). Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. J Pineal Res. 47:330-338.

Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C. y Parkin, D.M. 2010. Estimates of worldwide burden of cancer in (2008): GLOBOCAN 2008. Int J Cancer. 127:2893-917.

Grant, S.G., Melan, M.A., Latimer, J.J., Witt-Enderby, P.A. (2009). Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Rev Mol Med. 11: e5.

Hanahan, D. y Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell. 144:646-674.

Khare, S.P., Sharma, A., Deodhar, K.K., y Gupta, S. (2011). Overexpression of histone variant H2A.1 and cellular transformation are related in Nnitrosodiethylamine-induced sequential hepatocarcinogenesis. Exp Biol Med (Maywood). 236:30-5.

Kew, MC. (2002). Epidemiology of hepatocellular carcinoma. Toxicology. 181- 182:35-38.

López-Abente Ortega, G., Pollán Santamaría, M., Aragonés Sanz, N. y Pérez Gómez, B. (2005). La Situación del Cáncer en España. Centro de Publicaciones del Ministerio de Sanidad y Consumo, Madrid.

Martín-Renedo, J., Mauriz, J.L., Jorquera, F., Ruiz-Andrés, O., González, P. y González-Gallego, J. (2008). Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res. 45:532-540.

Mauriz, J.L., Durán, M.C., Molpeceres, V., Barrio, J.P., Martín-Renedo, J., Culebras, J.M., González-Gallego, J. y González P. (2007a). Changes in the antioxidant system by TNP-470 in an in vivo model of hepatocarcinoma. Transl Res. 150:189-196.

Mauriz, J.L., Gonzalez, P., Duran, M.C., Molpeceres, V., Culebras, J.M. y Gonzalez-Gallego, J. (2007b). Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. Transl Res. 149:46-53.

Mauriz, J.L., Linares, P., Macias, R.I., Jorquera, F., Honrado, E., Olcoz, J.L., González, P. y González-Gallego, J. (2003). TNP-470 inhibits oxidative stress, nitric oxide production and nuclear factor kappa B activation in a rat model of hepatocellular carcinoma. Free Radic Res. 37:841-848.

Mauriz, J.L., Molpeceres, V., García-Mediavilla, M.V., González, P., Barrio, J.P. y González-Gallego, J. (2007c). Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res. 42:222-230.

Molpeceres, V., Mauriz, J.L., García-Mediavilla, M.V., González, P., Barrio, J.P. y González-Gallego, J. (2007). Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis. J Gerontol A Biol Sci Med Sci. 62:687-695.

Tan, D.X., Hardeland, R., Manchester, L.C., Paredes, S.D., Korkmaz, A., Sainz, R.M., Mayo, J.C., Fuentes-Broto, L. y Reiter, R.J. (2010). The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness. Biol Rev Camb Philos Soc. 85:607-623.

Tan, Y.J. (2011). Hepatitis B virus infection and the risk of hepatocellular carcinoma. World J Gastroenterol. 17:4853-4857.

Toualbi, K., Güller, M.C., Mauriz, J.L., Labalette, C., Buendia, M.A., Mauviel, A. y Bernuau, D. (2007). Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. Oncogene. 26:3492-3502.

Toualbi-Abed, K., Daniel, F., Güller, M.C., Legrand, A., Mauriz, J.L., Mauviel, A., Bernuau, D. (2008). Jun D cooperates with p65 to activate the proximal kappaB site of the cyclin D1 promoter: role of PI3K/PDK-1. Carcinogenesis. 29:536-543.

Publicado

2018-07-02

Como Citar

Mauriz, J. L., Carbajo Pescador, S., & Martín Renedo, J. (2018). Investigación básica sobre hepatocarcinoma en la Universidad de León. Ambiociencias, (9), 39–56. https://doi.org/10.18002/ambioc.v0i9.4934

Edição

Seção

Baúl de la ciencia

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