Ensayos sobre la eficacia del Haloxon contra Trichinella spiralis

Authors

  • Miguel Cordero del Campillo Universidad de León
  • Benito M. Aller Gancedo Universidad de Oviedo
  • Antonio R. Martínez Fernández Universidad Complutense de Madrid

DOI:

https://doi.org/10.18002/analesdeveterinaria.v12.8899

Keywords:

Farmacodinámica animal, Haloxon, Parasitología animal, Sanidad animal, Triquinosis

Abstract

Three experiments have heen carried out to determine the effectiveness of Haloxon against Trichinella spiralis in artificially infected white rats and hamsters, at various stages in the life cycle of the worm. A commercial product (a wettable powder with 43.5 % of active ingredient ) was given as a
suspension in water per os, by means of a stomach tube. At a dose rate of 140 mg/kg it was very effective against adult worms, the reduction obtained in the number of muscle larvae in both species being above 90 %. Doses of 280 mg/kg completely eliminated the adult worms in rats, the statistical analyses of the results showing their positive
significance. Against haematic and pre-capsular larvae (9th to 18th days p.i.) a reduction of more than 30% was
always found in the experimental host as compared whit the untreated controls but these results
were without statistical significance. lncreasing doses did not give any better results

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Published

1966-01-02

Issue

Section

Research papers