Contribución al estudio de la influencia de las desmetilimipramina (DMI) sobre determinadas respuestas vegetativas

Authors

  • Antonio Prieto Yanes Universidad de Oviedo

DOI:

https://doi.org/10.18002/analesdeveterinaria.v12.8905

Keywords:

Farmacodinámica animal, Catecolaminas, Acetilcolina, Desmetilimipramina (DMI), Hipertensión

Abstract

A study has been carried out on the influence of Dimethylimipramine (DMI) on the neuro-vegetative system, specially on the hypertensor effect caused by: 1st.) high doses of acetyl-cholein in an atropinized animal; 2nd.) hypertension caused by carotid occlusion; 3rd.) hypertension caused by inoculation of catecholamines. A study has also been carried out on the effect of DMI on the contraction of the haw of a cat, caused by ganglial stimulation on the cervical sympathicus.
The tests were carried out on spinal cats or on cats treated with chloralose by utilizing, sometimes, the bilateral adrenalectomy. We have observed how the injection of DMI transitorily diminishes the pressing effect of ACH under the conditions of the test. It seems that this effect is due to the action of DMI on the liberation of adrenal catecholamines caused by ACH, DMI diminishes the pressing effect caused by the carotid occlusion.
The hypertension obtained by injecting PEAC (phenyl-ethyl-ace- tyl-cholein) is diminished by DMI in the adrenalectomized cat

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Published

1966-01-02

Issue

Section

Research papers