Acción de algunos metales divalentes sobre la inhibición de la Lipasa Pancreática por Tetraciclina y 4-Epi-Tetraciclina

Abstract

The libertion of butyric acid from glyceryl tributyrate through pancreatic lipase action has been utilized as an enzymatic system in thc study of tetracyclinc ami 4-epi-tctracycline inhi­bitory action.
Under our work conditions metals such as Mn²⁺, Co²⁺, Ni²⁺, or tetracyclinc and 4-cepi­tetracycline do not practically inhibit the enzyme if they are usced alone. Tetracycline anda also 4-epi-telracycline inhibit the action of pancreatic lipase in prcesence of metals such as Mn²⁺, Co²⁺ and Ni²⁺. Thix inhibition depends on the pH of the mixture of the reaction; it increases a as the reaction is higher.
The results found by the authors are applied to the study of the mecanism of action of tetracyclines.