Field and laboratory experiencies with an antiaphtous vaccine for pigs, inactivated with eei and with deae-dextran as an adjuvant

Abstract

A vaccine against foot-and-mouth disease, prepared from tissue culture ( a continous cell line from bull calf testis), concentrated by means of polyethylene glycol, inactivated with ethyl-etylene-imine (EEI) and with DEAE-Dextran as an adjuvant, has been studied under laboratory (197 pigs) and field conditions (1,416 pigs). A single 10 ml dose, divided into two 5 ml injected on each side of the neck, by intramuscular route has been used.
lnnocuity (local and general reaction), effect on growth rate, protec­tion, both immediate and lasting immunity and comparison tests with two aluminum hydroxide vaccines (a normal and a concentrated one, saponine added) proved very satisfactory. A spectacular immediate protec­tion suggest the possibility of controlling FMD outbreaks in the field by mass vaccination. The level of protection is enough to cover the fattening period of piglets up to the time to send them to the abattoir. Should the animals be kept for longer, revaccination is suggested.